The first sign of Crohn's disease,
Anal lesions
Perianal lesions can be the first sign that occurs more than 6 months before diagnosis in approximately 17.2% of all Crohn's disease patients. It is reported that fistula occurs in 10-26% of Crohn's disease patients worldwide, and compared to simple fistulas, complex fistulas are more difficult to treat and have a lower probability of Crohn's disease remission.
Cumulative Incidence of Perianal Disease
* The prevalence of fistula varies depending on the location of the disease: 12% for ileal disease alone, 15% for ileocolonic disease, 41% for colonic disease, and it is most severe at 92% when the rectum is involved.