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Autoimmune Disease

What is an Autoimmune Disease?

Malfunction of the immune system, inflammation that does not distinguish between self and non-self

"The most important function the immune system should have,
inflammation occurs due to a problem with self/non-self recognition."

Immune System

The Army and Police
Protecting My Body

Our body's immune system plays the role of protecting and defending our body. If we compare a person's body to a country, the immune system can be described as an organization like an army that prevents and defends against foreign invasions, or police that maintain the country's security and order.

Cases where enemies cross the border to invade are like bacterial or viral infections, and our body's immune system acts as an army fighting against the viruses or bacteria that have invaded from the outside.

Also, just as criminals who break the law appear within a country, cells that need to be removed—such as cells that have divided incorrectly or damaged cells—can occur inside our body, and the immune system acts like the police catching criminals in these instances.

An autoimmune disease is a condition where, due to a problem in the function of the immune system that acts like an army or police, it recognizes its own normal cells, tissues, or organs as enemies and attacks them.

In short, an autoimmune disease is a condition where a problem occurs in the self/non-self recognition function—the most important function the immune system should have, which is the ability to distinguish between its own normal cells, abnormal cells, or external infections—causing it to attack without distinguishing between self and non-self, resulting in inflammation.

It is most appropriate to think of it as a malfunction of the immune system.

Army protecting my body
Causes

Causes of Autoimmune Disease

The causes of autoimmune diseases have not yet been fully identified, but it is known that various factors act in combination.

Genetic Factors

The risk of developing the disease increases if there is a family history.

Environmental Factors

Causes such as infection, smoking, stress, chemical drugs, and environmental pollution.

Hormonal Factors

The risk of developing the disease is generally higher in women.

Immune Regulation Abnormalities

Causes such as the production of autoantibodies or overactivation of immune cells.

Classification

Classification Based on
Scope of Involvement

Autoimmune diseases are broadly classified into two types based on the scope of involvement.

SYSTEMIC

Systemic Autoimmune Disease

  • Systemic Lupus Erythematosus (SLE): Involves skin, joints, kidneys, nervous system, etc.
  • Rheumatoid Arthritis: Involves systemic joints or organs.
  • Systemic Sclerosis: Fibrosis of the skin and internal organs.
  • Sjogren's Syndrome: Oral and ocular dryness due to inflammation of salivary and tear glands.
ORGAN-SPECIFIC

Cases Involving Specific Organs

  • Hashimoto's Thyroiditis: Hypothyroidism.
  • Graves' Disease: Hyperthyroidism.
  • Multiple Sclerosis: Nerve damage.
  • Inflammatory Bowel Disease (IBD): Involves digestive organs such as the duodenum, small intestine, and large intestine.
  • Myasthenia Gravis: Muscle weakness due to nerve-muscle abnormalities.
Inflammatory Bowel Disease

What is Inflammatory Bowel Disease (IBD)?

Most autoimmune diseases are chronic, with symptoms repeatedly improving and worsening, and it is known that there is no appropriate cure in modern Western medicine.

Inflammatory Bowel Disease (IBD) is a disease in which chronic inflammation repeatedly occurs in the entire bowel or a part of the bowel.

Types of IBD

Types of Inflammatory Bowel Disease

Inflammatory Bowel Disease can be broadly divided into two types and an indeterminate type.

Ulcerative Colitis

Ulcerative Colitis (UC)

Inflammation and ulcers occurring in the colon mucosa

Ulcerative Colitis (UC)

90% of patients experience inflammation in the rectum, the end of the colon, which can spread throughout the entire colon.

Representative symptoms: Bloody stool, mucous stool, diarrhea, abdominal pain, weight loss

Crohn's Disease

Crohn's Disease (CD)

Inflammation across the entire digestive tract and through all layers

Crohn's Disease (CD)

Inflammation can occur discontinuously across all layers of the entire digestive tract from the esophagus to the colon.

Possibility of complications such as intestinal perforation, fistula, stenosis, and anal fistula
Representative symptoms: Abdominal pain, diarrhea, fatigue, weight loss

Indeterminate Type

Indeterminate

Inflammatory bowel disease that is difficult to confirm

Indeterminate

Accounts for 15-20% of all inflammatory bowel disease patients.

It is difficult to diagnose as ulcerative colitis or Crohn's disease, or the diagnosis may change after several years.

Prevalence

Status of Prevalence by Country

The prevalence of inflammatory bowel disease is increasing rapidly worldwide.
The increase is particularly notable in Asian countries, including Korea, while Western countries such as the United States already show high prevalence rates.

Korea

South Korea (Korea)

Surged by over 30% in 5 years

The number of inflammatory bowel disease patients in Korea has rapidly increased by over 30%, from approximately 70,000 in 2019 to 92,665 in 2023.

This is presumed to be primarily caused by changes in Westernized dietary habits and an increase in the number of diagnoses through health checkups.

Overseas Status (Japan/USA)

Japan Japan (2023 Statistics)
  • Ulcerative Colitis: Approx. 316,900 patients
  • Crohn's Disease: Approx. 95,700 patients
  • Total patients: Estimated approx. 410,000
USA USA (High Prevalence)

Corresponds to 0.7-0.8% of the total population, showing a significantly higher prevalence than other countries.

  • Ulcerative Colitis: Approx. 1.25 million
  • Crohn's Disease: Approx. 1.01 million
  • Total patients: Estimated 2.4 million to 3.1 million

F.A.Q

Frequently Asked Questions

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